<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">foodindustry</journal-id><journal-title-group><journal-title xml:lang="ru">Пищевая промышленность: наука и технологии</journal-title><trans-title-group xml:lang="en"><trans-title>Food Industry: Science and Technology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-4794</issn><publisher><publisher-name>Научно-практический центр Национальной академии наук Беларуси по продовольствию</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">foodindustry-600</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>История и стратегии персонализированного питания</article-title><trans-title-group xml:lang="en"><trans-title>History and str"ategies of personalized nutrition</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шилов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shylau</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шилов Валерий Викентьевич, кандидат биологических наук, доцент кафедры экологической медицины</p><p>ул. Долгобродская, д. 23/1, 220070, г. Минск</p></bio><bio xml:lang="en"><p>Shilov Valeriy Vikentievich, PhD (Вiology), Associate Professor of the Department of Ecological Medicine and Radioblology</p><p>Dolgobrodskaya st., 23/1, 220070, Minsk</p></bio><email xlink:type="simple">valefY.Shilov@gmall.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Батян</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Batijn</surname><given-names>А. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Батян Анатолий Николаевич, доктор медицинских наук, профессор, заведующий кафедрой экологической медицины и радиобиологии</p><p>ул. Долгобродская, д. 23/1, 220070, г. Минск</p></bio><bio xml:lang="en"><p>Batyan Anatoly Nilrolaevich, Doctor of Medical Sciences, Professor, Head of the Department of Ecological Medicine and Radioblology</p><p>Dolgobrodskaya st., 23/1, 220070, Minsk</p></bio><email xlink:type="simple">ant_b@tut.by</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>«Международный государственный экологический институт им. А.Д Сахарова» Белорусского государственного университета</institution></aff><aff xml:lang="en"><institution>"International State Ecological Institute named after A.D. Sakharov" Belarusian State University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>26</day><month>06</month><year>2023</year></pub-date><volume>16</volume><issue>2</issue><fpage>49</fpage><lpage>55</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шилов В.В., Батян А.Н., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Шилов В.В., Батян А.Н.</copyright-holder><copyright-holder xml:lang="en">Shylau V.V., Batijn А.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://foodindustry.belal.by/jour/article/view/600">https://foodindustry.belal.by/jour/article/view/600</self-uri><abstract><p>В последние десятилетия отмечается существенный рост метаболических нарушений, включающих инсулинорезистентность, атерогенную дислипидемию, артериальную гипертензию и ожирение. Важное место в процессе лечения этих заболеваний занимают диетические стратегии. Однако существующие в настоящее время диетические рекомендации основаны лишь на обобщении данных о потреблении питательных веществ у всех людей, но они не конкретизированы для каждого человека. Недавно была разработана новая концепция персонализированного питания, согласно которой диета становится фактором, ответственным не только за метаболические реакции организма, например постпрандиальные пики глюкозы, но и за другие факторы, важнейшим из которых является микробиота кишечника. Будущее персонализированного питания представляется в создании алгоритмов, основанных на характеристиках потребляемой пищи, биохимических параметрах, физической активности, генетической вариабельности и кишечной микробиоте. Все эти данные необходимы для прогнозирования определенного типа диеты для конкретного человека в соответствии с ero потребностями и метаболическими особенностями. Персонализация- это тенденция, которая сохранится надолго. Подавляющее число потребителей считают персонализацию привлекательной. Большое количество крупных мировых компаний работает в этой области. Отрасль персонализированного питания делится на три сеrмента: питание, активные инструменты измерения (диагностика) и услуги. Растущая распространенность здорового образа жизни станет движущим фактором роста рынка персонализированного питания.</p></abstract><trans-abstract xml:lang="en"><p>In recent decades, there has been а significant increase in metabolic disorders, including insulin resistance, atherogenic dyslipidemia, arterial hypertension and obesity. Dietary straiegies play an important role in the treatment ofthese diseases. However, current clietary recommendations are bascd only on summaries of nutrient intak:c data for all individuals and arc not specific to cach inclividual. Recently, а new concept of personalized nutrition has been developed, according to which cliet becomes а factor responsible not only for the body's rnetabolic responses, such as postprandiaJ glucose peaks, but also for other factors, the most important of which is the intestinal microhiota. The future of personalized nutrition appears to bе in the creation of algorithms based on the characteristics of food consumed, blochemical parameters, physical activity, genetic variability, and iniestinal microblota. All of this data is needed of predict а certain type of diet for а particular person according to his needs and metabolic characteristics. Personalization is а Irend that will continue for а long time. The vast majority of consumers find personalization appealing. А large number of large global companies are working in this area. The personalized nutrition industry is divided into three segments: nutrition, active measurement tools (diagnostics), and services. The growing prevalence of healthy lifestyles will bе the driving force behind the growth of the personalized nutrition market.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>персонализированное питание</kwd><kwd>нутригенетика</kwd><kwd>нутригеномика</kwd><kwd>микробиота</kwd><kwd>рынок услуг персонализированного питания</kwd></kwd-group><kwd-group xml:lang="en"><kwd>personalized nutrition</kwd><kwd>nutrigenetics</kwd><kwd>nutrigenomics</kwd><kwd>microblota</kwd><kwd>market for personalized nutrition services</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Collaborators, G.B. Health effects of overweight and obesity in 195 countries over 25 yeaxs/ G.B. Collaborators, А. Afshin, М .Н. Forouzanfar et al. /1 N Engl J Меd. - 2017. - Vol. 377. - Р. 1З-27.</mixed-citation><mixed-citation xml:lang="en">Collaborators, G.B. Health effects of overweight and obesity in 195 countries over 25 yeaxs/ G.B. Collaborators, А. Afshin, М .Н. Forouzanfar et al. /1 N Engl J Меd. - 2017. - Vol. 377. - Р. 1З-27.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Murphy, S.P. Нistory of nutrition:the long road 1eading to the dietary reference intakes for the United States and Canada / S.P. Мurphy, А.А Yates, S.A Atkinson et al. // Adv Nutr. - 2016.- Vo1. 7.- Р. 157-168.</mixed-citation><mixed-citation xml:lang="en">Murphy, S.P. Нistory of nutrition:the long road 1eading to the dietary reference intakes for the United States and Canada / S.P. Мurphy, А.А Yates, S.A Atkinson et al. // Adv Nutr. - 2016.- Vo1. 7.- Р. 157-168.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ahdelhamid, А. Нigh variahility of food and nutrient intake exists across the Мediterтanean dietary pattem-a systematic review /А Abdelhamid, А Jennings, R.P. Hayhoe et al. // Food Sci Nutr. - 2020. - Vol. 8. - Р. 4907-4918.</mixed-citation><mixed-citation xml:lang="en">Ahdelhamid, А. Нigh variahility of food and nutrient intake exists across the Мediterтanean dietary pattem-a systematic review /А Abdelhamid, А Jennings, R.P. Hayhoe et al. // Food Sci Nutr. - 2020. - Vol. 8. - Р. 4907-4918.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Ordovas, J. М. Nutrigenomics and nutrigenetics / J.М. Ordovas, V. Мooser // Curr Opin Lipido1.- 2004.- Vol. 15.- P.lOl-108.</mixed-citation><mixed-citation xml:lang="en">Ordovas, J. М. Nutrigenomics and nutrigenetics / J.М. Ordovas, V. Мooser // Curr Opin Lipido1.- 2004.- Vol. 15.- P.lOl-108.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Torres, N. Nutrigenomics as а tool in the prevention of lipotoxicity: the case of soy protein / N. Топеs, I. Toпe-Villalvazo, А R.Tovar // Rev Invest Clin.- 2019.- Vo1. 71. -Р. 157-167.</mixed-citation><mixed-citation xml:lang="en">Torres, N. Nutrigenomics as а tool in the prevention of lipotoxicity: the case of soy protein / N. Топеs, I. Toпe-Villalvazo, А R.Tovar // Rev Invest Clin.- 2019.- Vo1. 71. -Р. 157-167.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Guevara-Cruz, М. Effect of а GFOD2 variant on responses in total and LDL cholesterol in Мexican subjects with hypercholesterolemia after soy protein and soluble fiber supplementation. М. Guevara-Cruz, C.Q. Lai, К. Richardson et al.// Gene.- 2013.- Vol. 532.- Р. 211-215.</mixed-citation><mixed-citation xml:lang="en">Guevara-Cruz, М. Effect of а GFOD2 variant on responses in total and LDL cholesterol in Мexican subjects with hypercholesterolemia after soy protein and soluble fiber supplementation. М. Guevara-Cruz, C.Q. Lai, К. Richardson et al.// Gene.- 2013.- Vol. 532.- Р. 211-215.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Berry, S. Е. Human postprandial responses to food and potential for precision nutrition 1 S.E. Berry, АМ. Valdes, D.A Drew et al.// Nat Med. - 2020. - Vol. 26. - Р. 964-973.</mixed-citation><mixed-citation xml:lang="en">Berry, S. Е. Human postprandial responses to food and potential for precision nutrition 1 S.E. Berry, АМ. Valdes, D.A Drew et al.// Nat Med. - 2020. - Vol. 26. - Р. 964-973.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Zeevi,D. Personalized nutrition bу prediction of glycemic responвes 1 D. Zeevi, Т. Korem, N. Zmora et al. // Cell.- 2015.- Vo1. 163.- Р. 1079-1094.</mixed-citation><mixed-citation xml:lang="en">Zeevi,D. Personalized nutrition bу prediction of glycemic responвes 1 D. Zeevi, Т. Korem, N. Zmora et al. // Cell.- 2015.- Vo1. 163.- Р. 1079-1094.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kennedy, М. S. The microЬiomc:composition and locations 1 M.S. Kennedy, Е. В. Chang // Prog Mol Biol Transl Sci.- 2020.- Vol. 176.- P.l-42.</mixed-citation><mixed-citation xml:lang="en">Kennedy, М. S. The microЬiomc:composition and locations 1 M.S. Kennedy, Е. В. Chang // Prog Mol Biol Transl Sci.- 2020.- Vol. 176.- P.l-42.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Backhed, F. The gut microbiota as an environmental factor that regu]ates fat storage /F. Backhed, Н. Ding, Т. Wang et al. // Proc Natl Acad Sci U S А - 2004. - Vol. 101. - Р. 15718 -15723.</mixed-citation><mixed-citation xml:lang="en">Backhed, F. The gut microbiota as an environmental factor that regu]ates fat storage /F. Backhed, Н. Ding, Т. Wang et al. // Proc Natl Acad Sci U S А - 2004. - Vol. 101. - Р. 15718 -15723.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Dominguez-Bello, М. G. Delivery mode shapes the acquisition and structure of the initial microbiota across multip1e body habitats in newborns 1 М.G. Dominguez-Bello, Е.К. Costello, М. Contreras et al. // Proc Natl Acad Sci U S А- 2010.- Vol. 107.- Р. 11971-11975.</mixed-citation><mixed-citation xml:lang="en">Dominguez-Bello, М. G. Delivery mode shapes the acquisition and structure of the initial microbiota across multip1e body habitats in newborns 1 М.G. Dominguez-Bello, Е.К. Costello, М. Contreras et al. // Proc Natl Acad Sci U S А- 2010.- Vol. 107.- Р. 11971-11975.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Вlaser, М. J. Antibiotic use and its consequences for the normal microbiome / M.J. Вlaser // Science. - 2016. - Vol. 352. - Р. 544-545.</mixed-citation><mixed-citation xml:lang="en">Вlaser, М. J. Antibiotic use and its consequences for the normal microbiome / M.J. Вlaser // Science. - 2016. - Vol. 352. - Р. 544-545.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Medina- Vera, L А. dietary intervention with functional foods reduces metabolic endotoxaemia and attenuates biochemical abnonalities bу modifying faecal microbiota in people with Туре 2 diabetes / I. Medina-Vera, М. Sanchez-Tapia, L. Noriega-Lopez et al. // Diabetes Metab.- 2019. - Vol. 45. - Р. 122- 131.</mixed-citation><mixed-citation xml:lang="en">Medina- Vera, L А. dietary intervention with functional foods reduces metabolic endotoxaemia and attenuates biochemical abnonalities bу modifying faecal microbiota in people with Туре 2 diabetes / I. Medina-Vera, М. Sanchez-Tapia, L. Noriega-Lopez et al. // Diabetes Metab.- 2019. - Vol. 45. - Р. 122- 131.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Sanchez- Tapia, М. Diet as regulator of gut microblota and its role in health and disease/ М. Sanchez-Tapia, A.R. Tovar, N. Torres // Arch Med Res. - 2019. - Vol. 50. - Р. 259-268.</mixed-citation><mixed-citation xml:lang="en">Sanchez- Tapia, М. Diet as regulator of gut microblota and its role in health and disease/ М. Sanchez-Tapia, A.R. Tovar, N. Torres // Arch Med Res. - 2019. - Vol. 50. - Р. 259-268.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Cani, Р. D. Changes in gut microbiota contro1 metabolic endotoxemia-induced inflammation in blgh-fat diet-induced obesity and diabetes in mice 1 P.D. Cani, R. Bibiloni, С. Кnauf et al. // Diabetes.- 2008.- Vol. 57.- Р. 1470-1481.</mixed-citation><mixed-citation xml:lang="en">Cani, Р. D. Changes in gut microbiota contro1 metabolic endotoxemia-induced inflammation in blgh-fat diet-induced obesity and diabetes in mice 1 P.D. Cani, R. Bibiloni, С. Кnauf et al. // Diabetes.- 2008.- Vol. 57.- Р. 1470-1481.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Cavalot, F. Postprandial food glucose predicts cardiovascular events and all-cause mortality in Туре 2 diabetes in а 14-year follow-up:lessons from the San Lulgi Gonzaga diabetes study. F. Cavalot, А. Pagliarino, М. Valle et al. // Diabetes Care.- 2011.- Vol. 34.- Р. 2237-2243.</mixed-citation><mixed-citation xml:lang="en">Cavalot, F. Postprandial food glucose predicts cardiovascular events and all-cause mortality in Туре 2 diabetes in а 14-year follow-up:lessons from the San Lulgi Gonzaga diabetes study. F. Cavalot, А. Pagliarino, М. Valle et al. // Diabetes Care.- 2011.- Vol. 34.- Р. 2237-2243.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Sondertoft, N.B. The intestinal microblome is а co-determinant of the postprandial plasma glucose response 1 N.B. Sondertoft, М. Arumugam, J.К. Vogt et al. 11 PLoS One. - 2020 . -Vol. 15, N9.- е0238648.</mixed-citation><mixed-citation xml:lang="en">Sondertoft, N.B. The intestinal microblome is а co-determinant of the postprandial plasma glucose response 1 N.B. Sondertoft, М. Arumugam, J.К. Vogt et al. 11 PLoS One. - 2020 . -Vol. 15, N9.- е0238648.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Fontana, А. Gut microbiota profiles differ among individuals depending on their reglon of origin:An Italian pilot study /А. Fontaua, С. Panebianco, А. Picchianti-Diamanti et al.// Int J Environ Res Public Health.- 2019.- Р. 164065.</mixed-citation><mixed-citation xml:lang="en">Fontana, А. Gut microbiota profiles differ among individuals depending on their reglon of origin:An Italian pilot study /А. Fontaua, С. Panebianco, А. Picchianti-Diamanti et al.// Int J Environ Res Public Health.- 2019.- Р. 164065.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Не, У. Regional variation limits applications of healthy gut microbiome reference ranges and diseasemodels/Y. Не, W. Wu, У.М. Zhengetal. //NatMed.- 2018.- Vol. 24. -Р.1532-1535.</mixed-citation><mixed-citation xml:lang="en">Не, У. Regional variation limits applications of healthy gut microbiome reference ranges and diseasemodels/Y. Не, W. Wu, У.М. Zhengetal. //NatMed.- 2018.- Vol. 24. -Р.1532-1535.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Gibbons, S.М. Defining microbiome health through а host lens / S.M. Gibbons 1/ mSysterns. - 2019. - Vol. 4.- Р. 1-119.</mixed-citation><mixed-citation xml:lang="en">Gibbons, S.М. Defining microbiome health through а host lens / S.M. Gibbons 1/ mSysterns. - 2019. - Vol. 4.- Р. 1-119.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Guevara-Cruz, М. Improvement oflipoprotein profile and metabolic endotoxemia bу а lifestyle intervention that modifies the gut microЬiota in subjects with metabolic syndrome/ М. GuevaraCruz, A.G. F1ores-Lopez, М. Aguilar-Lopez et al. 11 J Am Heart Assoc. - 2019. - Vol. 8. - е012401.</mixed-citation><mixed-citation xml:lang="en">Guevara-Cruz, М. Improvement oflipoprotein profile and metabolic endotoxemia bу а lifestyle intervention that modifies the gut microЬiota in subjects with metabolic syndrome/ М. GuevaraCruz, A.G. F1ores-Lopez, М. Aguilar-Lopez et al. 11 J Am Heart Assoc. - 2019. - Vol. 8. - е012401.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Guevara- Cruz, М. А. dietary pattem inc1uding nopal, chia seed, soy protein, and oat reduces serum triglycerides and glucose intolerance in patients with metabolic syndromej М. GuevaraCruz, A.R. Tovar, С.А. Aguilar-Sallnas et al. // J Nutr. -Vo1. 142. - Р. 64-69.</mixed-citation><mixed-citation xml:lang="en">Guevara- Cruz, М. А. dietary pattem inc1uding nopal, chia seed, soy protein, and oat reduces serum triglycerides and glucose intolerance in patients with metabolic syndromej М. GuevaraCruz, A.R. Tovar, С.А. Aguilar-Sallnas et al. // J Nutr. -Vo1. 142. - Р. 64-69.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Jenkins, D. J. Effect of а dietary portfolio of cho1esterol-lowering foods given at 2 levels of intensity of dietary advice on serum lipids in hyperlipidemia:a randomized controlled trial / D.J. Jenkins, P.J. Jones, В. Lamarche et al.// JАМА.- 2011.- Vol. 306.- Р. 831-839.</mixed-citation><mixed-citation xml:lang="en">Jenkins, D. J. Effect of а dietary portfolio of cho1esterol-lowering foods given at 2 levels of intensity of dietary advice on serum lipids in hyperlipidemia:a randomized controlled trial / D.J. Jenkins, P.J. Jones, В. Lamarche et al.// JАМА.- 2011.- Vol. 306.- Р. 831-839.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Choi, У. Natural Ьioactive compounds as potential browning agents in white adipose tissue/ У. Choi, L. Yu // Pharm Res.- 2021.- Vol. 38, N4.- Р.549-567.</mixed-citation><mixed-citation xml:lang="en">Choi, У. Natural Ьioactive compounds as potential browning agents in white adipose tissue/ У. Choi, L. Yu // Pharm Res.- 2021.- Vol. 38, N4.- Р.549-567.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Jardon , К М. Dietary macronutrients and the gut microbiome: а precision nutrition approach to irnprove cardiometabolic health / К.М. Jardon, Е. E.Canfora, G.Н. Goossens, Е. Е. Blaak // Gut.- 2022. -Vol. 71, Nб. -Р.1214-1226.</mixed-citation><mixed-citation xml:lang="en">Jardon , К М. Dietary macronutrients and the gut microbiome: а precision nutrition approach to irnprove cardiometabolic health / К.М. Jardon, Е. E.Canfora, G.Н. Goossens, Е. Е. Blaak // Gut.- 2022. -Vol. 71, Nб. -Р.1214-1226.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Li, В. Microbiota depletion impairs thermogenesis ofbrown adipose tissue and browning ofwhite adipose tissue /В. Li, L. Li, М. Li et al.// Cell Reports. - 2019. - Vol. 26. - Р.2720-2737.</mixed-citation><mixed-citation xml:lang="en">Li, В. Microbiota depletion impairs thermogenesis ofbrown adipose tissue and browning ofwhite adipose tissue /В. Li, L. Li, М. Li et al.// Cell Reports. - 2019. - Vol. 26. - Р.2720-2737.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Collier, R. Thc DNA-bascd diet/ R. Collicr // СМАJ. -2017.- Vol. 189, Nl.- Р. 40-41.</mixed-citation><mixed-citation xml:lang="en">Collier, R. Thc DNA-bascd diet/ R. Collicr // СМАJ. -2017.- Vol. 189, Nl.- Р. 40-41.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Leshem, А. The Gut Microblome and Individnal-Specific Responses to Diet /А. Leshem, Е. Segal, Е. Elinav // mSystems. - 2020.- Vol. 5, N5.- е00665-20.</mixed-citation><mixed-citation xml:lang="en">Leshem, А. The Gut Microblome and Individnal-Specific Responses to Diet /А. Leshem, Е. Segal, Е. Elinav // mSystems. - 2020.- Vol. 5, N5.- е00665-20.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kussmann, М. F. Raymond М. Affolter OMICS-driven blomarker discovefY in nutrition and health / М. Kussmann, F. Raymond М. Affolter /1 Journal of Вiotechnology. - 2006. - Vol.</mixed-citation><mixed-citation xml:lang="en">Kussmann, М. F. Raymond М. Affolter OMICS-driven blomarker discovefY in nutrition and health / М. Kussmann, F. Raymond М. Affolter /1 Journal of Вiotechnology. - 2006. - Vol.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
