Control of N-nitrosamines content in food products
Abstract
Recently, the countries of the Eurasian Union are actively pursuing a program on protection of the public from low-quality goods. One of the directions of this objective is the control of the content of substances harmful to human health, such as pesticides, antibiotics, preservatives, colorants, and little-known N-nitrosamines which are contained in the most popular food products. Study and analysis of new methods of research and control of nitroso compounds content is an important issue.
In consideration of the forgoing, the article is dedicated to the researches which are aimed at studying of nitroso compounds content in food products by modern means, which contribute to provision of the population with safe products in this area.
Exogenous and endogenous ways of formation of N-nitroso compounds and detection of these organic compounds in the environment and food products are analyzed. The latest tendencies of the world’s scientific researches on the nitroso compounds influence on a human body are studied. Modern methods of the detection of the carcinogens are considered. There is provided an information summary for the period of 2014-2016 on the nitrosamine research in various food products which was compiled by the Republican Control and Testing Complex for Foodstuffs Quality and Safety of the RUE “Scientific and Practical Centre for Foodstuffs of the National Academy of Sciences of Belarus”. Exceeds of the limit concentration levels were not identified. That shows that foodstuffs industry has achieved a new and safer level of food production.
In consideration of the forgoing, the article is dedicated to the researches which are aimed at studying of nitroso compounds content in food products by modern means, which contribute to provision of the population with safe products in this area.
Exogenous and endogenous ways of formation of N-nitroso compounds and detection of these organic compounds in the environment and food products are analyzed. The latest tendencies of the world’s scientific researches on the nitroso compounds influence on a human body are studied. Modern methods of the detection of the carcinogens are considered. There is provided an information summary for the period of 2014-2016 on the nitrosamine research in various food products which was compiled by the Republican Control and Testing Complex for Foodstuffs Quality and Safety of the RUE “Scientific and Practical Centre for Foodstuffs of the National Academy of Sciences of Belarus”. Exceeds of the limit concentration levels were not identified. That shows that foodstuffs industry has achieved a new and safer level of food production.
About the Authors
I. M. Pochitskaya
RUE “Scientific-Practical Centre for Foodstuffs of the National Academy of Sciences of Belarus”
Belarus
Belarus
Pochitskaya Iryna M. — Ph.D. (Agricultural), the head of the Republican control and testing complex for foodstuffs quality and safety
29 Kozlova street, Minsk 220037
O. L. Permyakova
RUE “Scientific-Practical Centre for Foodstuffs of the National Academy of Sciences of Belarus”
Belarus
Belarus
Permyakova Olga Leonidovna — the 1st grade chemical engineer of the Republican control and testing complex for foodstuffs quality and safety
29 Kozlova street, Minsk 220037
References
1. Pavlov N.N. Riski dlya zdorov'ya detey i podrostkov, obuslovlennyye kontaminatsiyey pishchevykh produktov i syr'ya mestnogo proizvodstva. Diss.. k-t med. Nauk [Risks for the health of children and adolescents, caused by contamination of food and raw materials of local production. Cand. med. sci. diss.]: Volgograd, 2014. 150 p.
2. Distribution of Seven N-Nitrosamines in Food [Electronic resource] / Jong-eun Park, Jung-eun Seo, Jee-yeon Lee and Hoonjeong Kwon. -Toxicol Res. 2015 Sep; 31(3): 279-288 - Mode of access: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609975/. - Date of access: 15.08.2017.
3. Shutyuk V.V., Bessarab A.S., Vasilenko S.M., Kovbasa V.N. Issledovaniye protsessa obrazovaniya N-nitrozodimetilamina v protsesse sushki pivovarennogo soloda [Study of the process of N-nitrosodimethylamine formation in the process of brewing malt drying].Sb. nauch. tr. “Natsional'nyy universitet pishchevykh tekhnologiy. Khraneniye i pererabotka zerna” [Sat. sci. tr.« National University of Food Technologies. Storage and processing of grain»], 2014, no. 2, pp. 50-53.
4. Zaytseva N.V., Ulanova T.S., Nurislamova T.V., Popova N.A. Razrabotka gazokhromatograficheskogo metoda opredeleniya vysokotoksichnykh N-nitrozaminov (N-nitrozodimetilamin, N-nitrozodietilamin) v biologicheskikh sredakh (mocha) [Development of a gas chromatographic method for the determination of highly toxic N-nitrosamines (N-nitrosodimethylamine, N-nitrosodiethylamine) in biological media (urine)]. FBUN «Federal'nyy nauchnyy tsentr mediko-profilakticheskikh tekhnologi yupravleniya riskami zdorov'yu naseleniya» Federal'noy sluzhby po nadzoru v sfere zashchity prav potrebiteley i blagopoluchiya cheloveka. Gigiyena i sanitariya. [Federal Research Center for Medico- prophylactic technologies for managing public health risks "of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare. Hygiene and sanitation], 2014, no 3, pp. 88-92.
5. Zakrevskiy V.V., Zuykov V.A., Zakrevskaya A.V. Gosudarstvennaya sistema nadzora za bezopasnost'yu pishchevykh produktov v Rossii. [State system of food safety surveillance in Russia]. Sb. nauch. tr. Sankt-Peterburgskaya gosudarstvennaya meditsinskaya akademiya im. I. I. Mechnikova. “Ekologiya cheloveka” [Coll. sci. St. Petersburg State Medical Academy. I. I. Mechnikov “Human Ecology”], 2010, no. 09, pp. 3-8.
6. Ingestion Exposure to Nitrosamines in Chlorinated Drinking Water [Electronic resource] / Hekap Kim and Kichan Han-Environ Health Toxicol. 2011 Mar; 26. Mode of access: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214982/. - Date of access: 24.08.2017.
7. Li L. Influence of various cooking methods on the concentrations of volatile N-nitrosamines and biogenic amines in dry-cured sausages / L. Li, P. Wang, X. Xu, G. J. Zhou// J. Food Sci. - 2012. - Vol. 77, № 5.pp. 560-565.
8. Farren N.J. Estimated Exposure Risks from Carcinogenic Nitrosamines in Urban Airborne Particulate Matter / N.J. Farren, N. Ramírez, J.D. Lee, E. Finessi, A.C. Lewis, J.F. Hamilton // Environ. Sci. Technol. - 2015. - Vol. 49, № 16. -pp. 9648-9656.
9. Song P. Dietary Nitrates, Nitrites, and Nitrosamines Intake and the Risk of Gastric Cancer: A Meta-Analysis / P. Song, L. Wu, W. Guan // J. Nutrients.- 2015. - № 7. -pp. 9872-9895.
10. Galachiyev S.M., Makoyeva L.M., Dzhioyev F.K., KhayevaL.H. Vozmozhnosti endogennogo obrazovaniya nitrozaminov v zheludochnom soke in vitro [Possibilities of endogenous formation of nitrosamines in gastric juice in vitro]. Severo-Osetinskaya gosudarstvennaya meditsinskaya akademiya «Izvestiya Samarskogo nauchnogo tsentra Rossiyskoy akademii nauk» [North Ossetian State Medical Academy “Izvestiya of the Samara Scientific Center of the Russian Academy of Sciences”], 2011, vol. 13, no. 1(7), pp. 1678-1680.
11. Gordeyeva L.A.,Voronina E.N, Glushkov A.N. Geneticheskiye osobennosti metabolizma ksenobiotikov i predraspolozhennost' k patologii beremennosti. Chast' 1 [Genetic features of xenobiotic metabolism and predisposition to pregnancy pathology. Part 1]. Nauchno-prakticheskiy medetsinskiy zhurnal “Meditsina v Kuzbasse” [Scientific and practical medical journal «Medicine in the Kuzbass»], 2016, vol. 15, no. 2, pp. 8-16.
12. Instruktsiya № 107-1006-2007. Metodika opredeleniya nitrozaminov v pishchevykh produktakh i prodovol'stvennom syr'ye khromatograficheskimi metodami [Instruction No. 107-1006-2007. Method for determination of nitrosamines in food products and food raw materials by chromatographic methods]. Minsk, Ministerstvo zdravookhraneniya Respubliki Belarus', GU “Respub. nauchno-prakticheskiy tsentrgi giyeny” [Ministry of Health of the Republic of Belarus, PI “Respub. scientific and practical center of hygiene”], 2007.16 p.
13. Method for inhibiting nitrosamine formation in anion exchange resins: pat.US 9216411 B2 USA, B 01 J 41/04; B 01 J 47/00; B 01 J 47/04; C 08 G 14/06; C 08 K 5/32 / Chris Raymond Eicher, Daryl John Gisch; applicant DOW GLOBAL TECHNOLOGIES LLC (Midland, MI) - ID 45065806; appl. 27.12.11; publ. 22.12.15.
Review
For citations:
Pochitskaya I.M., Permyakova O.L. Control of N-nitrosamines content in food products. Food Industry: Science and Technology. 2018;11(2):87-94. (In Russ.)
Views: 338
Email this article 